1. Compared to  Invisalign aligners previously made from single-layer (EX30) material.  **In a study Miller et al, with adults measuring pain in the first week of treatment. Kevin Miller et al.  “A comparison of treatment impacts between Invisalign aligner and fixed appliance therapy during the first week of treatment.”  American Journal of Orthodontics and Dentofacial Orthopedics.  Volume 131, Issue 3, pp. 302. e1-302.e9, March 2007.”
  2. Based on a survey of n=2,752 Invisalign doctors who were asked, how much do you agree or disagree with the following statement: “Invisalign is the world’s most advanced digital orthodontic treatment system.” Doctors were surveyed in the USA, Canada, UK, Brazil, Germany, France, Spain, Italy, China, Japan, and ANZ. Data on file at Align Technology, as of July 10, 2020.
  3. As of 31st March 2021, data on file at Align Technology.
  4. With weekly aligner changes, compared with two-week aligner changes.
  5. Aligners made from SmartTrack material provide better fit, better comfort, and are easier to insert and remove compared to Invisalign aligners made from single-layer (EX30) material.
  6. Gu, J et al. Evaluation of Invisalign Treatment effectiveness and efficiency compared with conventional fixed appliances using the Peer Assessment Rating index. Am J Orthod Dentofacial Orthop February 2017, 151 259-66. Buschang, P et al Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthodontist, Vol 84, No 3, 2014.